Fluphenazine-N-2-chloroethane (hydrochloride)

A nitrogen mustard derivative of fluphenazine

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库存: 现货

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10mg

￥512.00

410.00

- +
25mg

￥1037.00

830.00

- +
50mg

￥1662.00

1330.00

- +
100mg

￥3112.00

2490.00

- +

已选 0 种 0 瓶

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货号: ajci71620
CAS: 3892-78-2
别名: Fluphenazine-N-mustard, FNM, FPCE, SKF-7171A
分子式: C22H25ClF3N3S?2HCl
分子量: 528.9
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM), which can sensitize cancer cells to TRAIL-induced apoptosis.