Ganglioside GM1 Asialo Mixture

A sphingolipid

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库存: 现货

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数量
500ug

￥4200.00

3360.00

- +
1mg

￥8012.00

6410.00

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货号: ajci71702
CAS: 71012-19-6
别名: 神经节苷脂
分子式: C62H114N2O23 (for Sphingosine C18:1)
分子量: 1255.6
纯度: >98%
溶解度: Chloroform:Methanol (2:1): Soluble
储存: Store at -20°C
库存: 现货

Background

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.