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  • Hedgehog Antagonist VIII
Hedgehog Antagonist VIII的可视化放大

Hedgehog Antagonist VIII

An inhibitor of hedgehog pathway signaling

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Hedgehog Antagonist VIII的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 500ug
    ￥1212.00
    970.00
    - +
  • 1mg
    ￥2037.00
    1630.00
    - +
  • 5mg
    ￥3625.00
    2900.00
    - +
  • 10mg
    ￥6050.00
    4840.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci71860
  • CAS: 330796-24-2
  • 别名: Hh Antagonist VIII
  • 分子式: C23H15ClF4N4O2
  • 分子量: 490.8
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.

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