IKK2 Inhibitor VI

An inhibitor of IKK2

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库存: 现货

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数量
500ug

￥1037.00

830.00

- +
1mg

￥1862.00

1490.00

- +
5mg

￥8100.00

6480.00

- +

已选 0 种 0 瓶

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货号: ajci72030
CAS: 354811-10-2
别名: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide
分子式: C12H11N3O2S
分子量: 261.3
纯度: >98%
溶解度: 2mg/mL in ethanol, 30mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). [1] It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.[2][3]

Reference:
[1]. Baxter, A., Brough, S., Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 2817-2822 (2004).
[2]. McNamara, L.A., Ganesh, J.A., and Collins, K.L. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. Journal of Virology 86(17), 9337-9350 (2012).
[3]. Punj, V., Matta, H., and Chaudhary, P.M. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One 7(5), 1-15 (2012).