Lanreotide (acetate)

A somatostatin receptor agonist

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库存: 现货

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1mg

￥212.00

170.00

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5mg

￥812.00

650.00

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10mg

￥1412.00

1130.00

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货号: ajci72306
CAS: 127984-74-1
别名: 醋酸兰瑞肽,BIM 23014 acetate
分子式: C54H69N11O10S2?XC2H4O2
分子量: 1096.3
纯度: >98%
溶解度: DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively). Lanreotide (100 nM) inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro. It also inhibits tumor growth in human small cell lung cancer (SCLC) mouse xenograft models when administered at a dose of 250 µg, twice daily. Formulations containing lanreotide have been used in the treatment of acromegaly and neuroendocrine tumors.