安捷凯生物医药
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  • Metamizole (sodium salt)
Metamizole (sodium salt)的可视化放大

Metamizole (sodium salt)

A nonopioid prodrug

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Metamizole (sodium salt)的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 25g
    ￥787.00
    630.00
    - +
  • 50g
    ￥1425.00
    1140.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci72576
  • CAS: 68-89-3
  • 别名: 安乃近
  • 分子式: C13H16N3O4S?Na
  • 分子量: 333.3
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects. MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC50s = 2.6 and 20.8 µM, respectively, and COX-2: IC50s = 4.7 and 41.8 µM, respectively). These metabolites can be further acylated with arachidonic acid to form compounds that can bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors at low micromolar concentrations.

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