Metoclopramide (hydrochloride)

An orally bioavailable 5-HT3 and D2 receptor antagonist

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库存: 现货

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10g

￥712.00

570.00

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25g

￥1687.00

1350.00

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50g

￥3225.00

2580.00

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100g

￥4937.00

3950.00

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货号: ajci72614
CAS: 7232-21-5
别名: 盐酸甲氧氯普胺
分子式: C14H22ClN3O2?HCl
分子量: 336.3
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine receptor 2 (D2) antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.