MitoPQ

A mitochondria-targeted redox cycler

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥687.00

550.00

- +
25mg

￥2612.00

2090.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.[1] Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.[1] Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.[1]

Reference:
[1]. Robb, E.L., Gawel, J.M., Aksentijevic, D., et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology & Medicine 89, 883-894 (2015).