安捷凯生物医药
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  • MK2 Inhibitor III
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MK2 Inhibitor III

A potent, cell-permeable inhibitor of MK2

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MK2 Inhibitor III的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 500ug
    ￥1050.00
    840.00
    - +
  • 1mg
    ￥1575.00
    1260.00
    - +
  • 5mg
    ￥3237.00
    2590.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci72664
  • CAS: 1186648-22-5
  • 别名:
  • 分子式: C21H16N4O?H2O
  • 分子量: 358.4
  • 纯度: >98%
  • 溶解度: DMF: 1.4 mg/ml,DMSO: 5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 µM).

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