Myrtillin

A natural anthocyanin

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500ug

￥1162.00

930.00

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货号: ajci72768
CAS: 6906-38-3
别名: 氯化飞燕草素葡萄糖苷; Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride
分子式: C21H21O12?Cl
分子量: 500.8
纯度: >98%
溶解度: DMF: 1.5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存: Store at -20°C, sealed storage, away from moisture and light
库存: 现货

Background

Myrtillin (Delphinidin 3-o-glucoside) is a kind of anthocyanin monomer, which is mainly distributed in various plants and can be analyzed qualitatively and quantitatively by high performance liquid chromatography (HPLC) Mass spectrometry (Mass) and nuclear magnetic resonance (NMR)

Myrtillin at 50 uM does not affect cell viability, also showing that delphinidin in association with lipopolysaccharide was able to induce MSC proliferation. Additionally, delphinidin modulated the MSC immune response, showing increased levels of anti-inflammatory cytokines such as IL-10 and TGF-β as well as lower expression of NFκB^[2]. Myrtillin showed potential for binding with and inhibiting immune checkpoints, PD-1 and PD-L1, which can activate immune response in the tumor microenvironment and induce cancer cell death^[3].

Myrtillin (20 mg/kg) decreased serum TG, TC, LDL-C, and HDL-C. Myrtillin (20 mg/kg) also reduced lipid levels in the liver and aorta. Myrtillin (20 mg/kg) down-regulated the mRNA levels of IL-6, VCAM-1, and NF-κB and up-regulated the mRNA levels of GSH-PX and SOD1.DP alleviated the HFD-induced oxidative stress and inflammation in atherosclerosis rabbits^[1].

参考文献:
[1]: Sun B, Li F, et,al.Delphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis. Pharm Biol. 2022 Dec;60(1):247-254. doi: 10.1080/13880209.2021.2017469. PMID: 35130117; PMCID: PMC8823684.
[2]: Bruna Roberta Oliveira Neves, Sumara de Freitas, et,al. Delphinidin-3-O-glucoside in vitro suppresses NFκB and changes the secretome of mesenchymal stem cells affecting macrophage activation,Nutrition,2022,111853,ISSN 0899-9007,
[3]: Mazewski C, Kim MS,et,al. Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico. Sci Rep. 2019 Aug 9;9(1):11560. doi: 10.1038/s41598-019-47903-0. PMID: 31399602; PMCID: PMC6689002.

桃金娘苷（Delphinidin 3-o-glucoside）是一种花青素单体，主要分布于各种植物中，可用高效液相色谱法（HPLC）质谱法（Mass）和核磁共振法进行定性和定量分析(NMR)

50 uM Myrtillin 不影响细胞活力，这也表明飞燕草素与脂多糖结合能够诱导 MSC 增殖。此外，飞燕草素调节 MSC 免疫反应，显示抗炎细胞因子水平升高，如 IL-10 和 TGF-β；以及 NFκB^[2] 的较低表达。 Myrtillin 具有结合和抑制免疫检查点 PD-1 和 PD-L1 的潜力，可激活肿瘤微环境中的免疫反应并诱导癌细胞死亡^[3]。

Myrtillin (20 mg/kg) 降低血清 TG、TC、LDL-C 和 HDL-C。 Myrtillin (20 mg/kg) 还可以降低肝脏和主动脉中的脂质水平。 Myrtillin (20 mg/kg) 下调 IL-6、VCAM-1 和 NF-κB 的 mRNA 水平并上调 GSH-PX 和 SOD1 的 mRNA 水平。DP 减轻了 HFD 诱导的氧化应激兔动脉粥样硬化和炎症^[1]。

Protocol

Cell experiment [1]:
Cell lines	MSCs
Preparation Method	The cells cultured for 24 hours with 50 uM of Myrtillin and stimulated or not with 1.25 g/mL of LPS.
Reaction Conditions	50 μM Myrtillin for 24 hours
Applications	50 μM Myrtillin increased the percentage of cells in the S/G2/M cycle phase. Mesenchymal stem cells produce soluble factors.
Animal experiment [2]:
Animal models	Rabbit
Preparation Method	A rabbit model of atherosclerosis (AS) was established by 12 weeks of a high-fat diet (HFD). The rabbits were divided into five groups: control, AS, simvastatin (4 mg/kg), and two Myrtillin groups (10 and 20 mg/kg). After treatment with Myrtillin or simvastatin by oral gavage for 12 weeks, the lipid profiles were measured.
Dosage form	10 and 20 mg/kg Myrtillin for 12 weeks
Applications	DP (20 mg/kg) decreased serum TG, TC, LDL-C, and HDL-C. Myrtillin (20 mg/kg) also reduced lipid levels in the liver and aorta. Myrtillin (20 mg/kg) down-regulated the mRNA levels of IL-6, VCAM-1, and NF-κB and up-regulated the mRNA levels of GSH-PX and SOD1.
参考文献: [1]: Bruna Roberta Oliveira Neves, Sumara de Freitas, et,al. Delphinidin-3-O-glucoside in vitro suppresses NFκB and changes the secretome of mesenchymal stem cells affecting macrophage activation,Nutrition,2022,111853,ISSN 0899-9007, [2]: Sun B, Li F, et,al. Delphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis. Pharm Biol. 2022 Dec;60(1):247-254. doi: 10.1080/13880209.2021.2017469. PMID: 35130117; PMCID: PMC8823684.