N-Arachidonoyl Taurine

An arachidonoyl amino acid

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库存: 现货

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数量
500ug

￥700.00

560.00

- +
1mg

￥1337.00

1070.00

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5mg

￥5587.00

4470.00

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10mg

￥9775.00

7820.00

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货号: ajci72876
CAS: 119959-65-8
别名:
分子式: C22H37NO4S
分子量: 411.6
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 20 mg/ml,PBS (pH 7.2): 1.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively). It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 µM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells. The levels of N-arachidonoyl taurine are changed in mouse brain following administration of δ9-tetrahydrocannabinol (δ9-THC).