N-Lignoceroyl Taurine

A FAAH substrate discovered during metabolite profiling

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1mg

￥1312.00

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5mg

￥5912.00

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10mg

￥10512.00

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货号: ajci73062
CAS: 807370-75-8
别名:
分子式: C26H53NO4S
分子量: 475.8
纯度: >98%
溶解度: DMF: 2.5 mg/ml,DMSO: 5 mg/ml,Ethanol: .15 mg/ml,PBS (pH 7.2): .1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain. N-lignoceroyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice. The levels of N-lignoceroyl taurine were elevated 23-26 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-lignoceroyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate N-lignoceroyl taurine is hydrolyzed 2,000 times more slowly by FAAH compared to oleoyl ethanolamide. N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.