NO-Indomethacin

An NSAID-NO donor hybrid with anti-cancer activity

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥325.00

260.00

- +
5mg

￥1487.00

1190.00

- +
10mg

￥2650.00

2120.00

- +
50mg

￥11500.00

9200.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci73120
CAS: 301838-28-8
别名: NCX 2121
分子式: C28H30ClN3O9S
分子量: 620.1
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2)(1:1): .5 mg/ml,DMSO: 20 mg/ml,Ethanol: .5 mg/ml
储存: Store at -20°C
库存: 现货

Background

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.