Norfluoxetine (hydrochloride)

An active metabolite of fluoxetine

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库存: 现货

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1mg

￥737.00

590.00

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5mg

￥3350.00

2680.00

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10mg

￥4650.00

3720.00

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货号: ajci73144
CAS: 57226-68-3
别名: 去甲氟西汀,Desmethylfluoxetine
分子式: C16H16F3NO?HCl
分子量: 331.8
纯度: >98%
溶解度: 30mg/mL in ethanol, 30mg/mL in DMSO, 30mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35 [1] . The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).[1][2]

Reference:
[1]. Wong, D.T., Bymaster, F.P., Reid, L.R., et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology 8(4), 337-344 (1993).
[2]. Hiemke, C., and H?rtter, S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & Therapeutics 85(1), 11-28 (2000).