Oleoyl Serinol

An analog of ceramide and a GPR119 agonist

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库存: 现货

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5mg

￥675.00

540.00

- +
10mg

￥1287.00

1030.00

- +
50mg

￥5412.00

4330.00

- +
100mg

￥9487.00

7590.00

- +

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货号: ajci73246
CAS: 72809-08-6
别名: NOleoyl Serinol, S18
分子式: C21H41NO3
分子量: 355.6
纯度: >98%
溶解度: DMF: >30 mg/ml,DMSO: >15 mg/ml,Ethanol: >30 mg/ml,PBS (pH 7.2): >290 μ g/ml
储存: Store at -20°C
库存: 现货

Background

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine neuroblastoma and apoptosis in U-87 human astrocytoma cells when used at a concentration of 100 µM. Oleoyl serinol (80 µM) induces formation of a complex including PAR-4 and PKCζ in embryoid body-derived cells, decreases the levels of the pluripotency marker Oct-4 and prostate apoptosis response-4 (PAR-4), which mediates ceramide-induced apoptosis in embryonic stem cells. It induces apoptosis selectively in rapidly dividing cells over differentiated cells as well as prevents teratoma formation and promotes neural differentiation in a neonatal mouse engraftment model of teratoma formation.