Oleyl Anilide

An ACAT inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥287.00

230.00

- +
10mg

￥562.00

450.00

- +
50mg

￥2312.00

1850.00

- +
100mg

￥4012.00

3210.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci73252
CAS: 5429-85-6
别名: OA, Oleic Acid Anilide, Oleylanilide
分子式: C24H39NO
分子量: 357.6
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存: Store at -20°C
库存: 现货

Background

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT) with an IC50 of 26 µM. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. The clinical consequences are an acute pulmonary inflammatory reaction followed by chronic neuropathy, myalgia, and autoimmune connective tissue disease, generally referred to as toxic oil syndrome (TOS). Aniline-denatured cooking oil is a source of OA associated with TOS.