Pemetrexed (sodium salt hydrate)

An antifolate with anticancer activity

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库存: 现货

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促销价

数量
5mg

￥875.00

700.00

- +
10mg

￥200.00

160.00

- +
50mg

￥900.00

720.00

- +
100mg

￥1350.00

1080.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci73424
CAS: 357166-29-1
别名: 培美曲赛二钠七水合物,LY231514 disodium heptahydrate
分子式: C20H19N5O6?2Na [7H2O]
分子量: 597.5
纯度: >98%
溶解度: PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Pemetrexed is pyrrotopyrimidine-based, multi-targeted antifolate with broad in vivo antitumor activity. Originally identified as a highly efficient substrate for folylpolyglutamate synthase, pemetrexed potently inhibits multiple folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM). Its antiproliferative activity has been demonstrated in a wide variety of solid tumors, including non-small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and neck.