Pramlintide (acetate hydrate)

An amylin analog

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库存: 现货

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5mg

￥4075.00

3260.00

- +
10mg

￥7762.00

6210.00

- +
25mg

￥18225.00

14580.00

- +
50mg

￥32375.00

25900.00

- +

已选 0 种 0 瓶

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货号: ajci73590
CAS: 196078-30-5
别名: 醋酸普兰林肽
分子式: C171H267N51O53S2?XC2H4O2 [XH2O]
分子量: 3949.4
纯度: >98%
溶解度: DMSO: 10 mg/ml,PBS (pH 7.2): 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.