Prednisolone Phosphate (sodium salt)

A prodrug form of prednisolone

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1g

￥800.00

640.00

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5g

￥3025.00

2420.00

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10g

￥5600.00

4480.00

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25g

￥10025.00

8020.00

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货号: ajci73598
CAS: 125-02-0
别名: 泼尼松龙21-磷酸二钠; Prednisolone 21-phosphate disodium
分子式: C21H27O8P?2Na
分子量: 484.4
纯度: >98%
溶解度: PBS (pH 7.2): 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].

参考文献:
[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95.
[2]. http://en.wikipedia.org/wiki/Prednisolone