PSB-1115 (potassium salt)

An adenosine A2B receptor antagonist

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库存: 现货

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5mg

￥1337.00

1070.00

- +
10mg

￥2562.00

2050.00

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25mg

￥5662.00

4530.00

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货号: ajci73708
CAS: 409344-71-4
别名: 1-丙基-8-(4-磺酸基苯基)黄嘌呤钾盐水合物
分子式: C14H13N4O5S?K
分子量: 388.4
纯度: >98%
溶解度: DMF: 5 mg/ml,DMSO: 25 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C, protect from light
库存: 现货

Background

PSB-1115 is an antagonist of the adenosine A2B receptor (Ki = 53.4 nM). [1]? It is selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively, and over the A3 receptor, which it inhibits only 14% at a concentration of 10 µM. PSB-1115 pre-treatment reduces relaxation of rat trachea induced by repeated dosing of the non-selective adenosine agonist NECA .[2]

Reference:
[1]. Hayallah, A.M., Sandoval-Ramírez, J., Reith, U., et al. 1,8-Disubstituted xanthine derivatives: Synthesis of potent A2B-selective adenosine receptor antagonists. J. Med. Chem. 45(7), 1500-1510 (2002).
[2]. Walaschewski, R., Begrow, F., and Verspohl, E.J. Impact and benefit of A2B-adenosine receptor agonists for the respiratory tract: Mucociliary clearance, ciliary beat frequency, trachea muscle tonus and cytokine release. J. Pharm. Pharmacol. 65(1), 123-132 (2013).