Riluzole-13C,15N2

An internal standard for the quantification of riluzole

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1mg

￥6137.00

4910.00

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货号: ajci73926
CAS: 1215552-03-6
别名: 利鲁唑-13C-15N2
分子式: C7[13C]H5F3[15N]2OS
分子量: 237.2
纯度: >98%
溶解度: Chloroform: Soluble,Methanol: Soluble
储存: Store at -20°C
库存: 现货

Background

Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.