安捷凯生物医药
全部分类
全部分类
  • RU-SKI 43 (hydrochloride)
RU-SKI 43 (hydrochloride)的可视化放大

RU-SKI 43 (hydrochloride)

An inhibitor of hedgehog acyltransferase

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

RU-SKI 43 (hydrochloride)的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 1mg
    ￥387.00
    310.00
    - +
  • 5mg
    ￥1225.00
    980.00
    - +
  • 10mg
    ￥1787.00
    1430.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
首页 收藏

使用我司产品发表的文章

  • 货号: ajci73952
  • CAS: 1782573-67-4
  • 别名: RU-SKI 43（盐酸盐）
  • 分子式: C22H30N2O2S?HCl
  • 分子量: 423
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Hedgehog acyltransferase (Hhat) is an N-palmitoyltransferase that acylates Sonic hedgehog (Shh), which is critical for signaling through Shh. RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 µM). It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription. In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation.

没有评价数据

一键回到顶部
展开 收缩

安捷凯在线客服

扫一扫加微信

扫一扫加微信

温馨提示 ×
商品已成功加入购物车！
购物车共 0 件商品
去购物车结算