SI-2

An inhibitor of SRC-3

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库存: 现货

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1mg

￥712.00

570.00

- +
5mg

￥2712.00

2170.00

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10mg

￥5025.00

4020.00

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25mg

￥11687.00

9350.00

- +

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货号: ajci74018
CAS: 380537-35-9
别名: EPH 116
分子式: C15H15N5
分子量: 265.3
纯度: >98%
溶解度: 20mg/mL in ethanol, 30mg/mL in DMSO or DMF
储存: Store at -20°C
库存: 现货

Background

SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.1 SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.[1] At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.[1]

Reference:
[1]. Song, X., Chen, J., Zhao, M., et al. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proceedings of the National Academy of Sciences of the United States of America 113(18), 4970-4975 (2016).