安捷凯生物医药
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  • Siomycin A
Siomycin A的可视化放大

Siomycin A

An inhibitor of FoxM1

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Siomycin A的二维码
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  • 500ug
    ￥6337.00
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使用我司产品发表的文章

  • 货号: ajci74026
  • CAS: 12656-09-6
  • 别名: 盐霉素 A
  • 分子式: C71H81N19O18S5
  • 分子量: 1648.9
  • 纯度: >98%
  • 溶解度: DMF: Soluble,DMSO: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 μM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.

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