SLF

A synthetic FK-506 Binding Protein (FKBP) ligand

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库存: 现货

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数量
5mg

￥925.00

740.00

- +
10mg

￥1712.00

1370.00

- +
50mg

￥6850.00

5480.00

- +
100mg

￥11375.00

9100.00

- +

已选 0 种 0 瓶

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货号: ajci74040
CAS: 195513-96-3
别名: Synthetic Ligand of FKBP
分子式: C30H40N2O6
分子量: 524.7
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:3): .2 mg/ml
储存: Store at -20°C
库存: 现货

Background

FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. Synthetic ligand of FKBP (SLF) is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin. By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment. For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM.