tetranor-12(S)-HETE

A peroxisome metabolite of 12(S)-HETE

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25ug

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货号: ajci74290
CAS: 121842-79-3
别名: tetranor-12(S)-Hydroxyeicosatetraenoic Acid
分子式: C16H26O3
分子量: 266.4
纯度: >98%
溶解度: 0.1 M Na2CO3: 2 mg/ml,DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): .5 mg/ml
储存: Store at -20°C
库存: 现货

Background

12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger's Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound.