TFMB-(R)-2-HG

A cell-permeable form of (R)-2-HG

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1mg

￥550.00

440.00

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5mg

￥2062.00

1650.00

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10mg

￥3162.00

2530.00

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25mg

￥5937.00

4750.00

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50mg

￥10250.00

8200.00

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100mg

￥17100.00

13680.00

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200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

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Background

TFMB-R-2-HG is a cell-permeable form of (R)-2-hydroxyglutarate ((R)-2-HG).¹ (R)-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.^2,3,4 TFMB-R-2-HG has been used to assess the role of (R)-2-HG in leukemogenesis.¹

1.Losman, J.A., Looper, R.E., and Koivunen, P.(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversibleScience339(6127)1621-1625(2013) 2.Yang, H., Ye, D., Guan, K.L., et al.IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectivesClin. Cancer Res.18(20)5562-5571(2012) 3.Xu, W., Yang, H., Liu, Y., et al.Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesCancer Cell19(1)17-30(2011) 4.Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al.The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesEMBO Rep.12(5)463-469(2011)