TIQ-A

A PARP1 inhibitor

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库存: 现货

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包装

价格

促销价

数量
500ug

￥450.00

360.00

- +
1mg

￥937.00

750.00

- +
5mg

￥3362.00

2690.00

- +
10mg

￥5337.00

4270.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci74356
CAS: 420849-22-5
别名:
分子式: C11H7NOS
分子量: 201.2
纯度: >98%
溶解度: DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml,DMSO: 10 mg/ml,Ethanol: 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis. TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.