安捷凯生物医药
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  • Triparanol
Triparanol的可视化放大

Triparanol

An inhibitor of DHCR24

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

Triparanol的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 500ug
    ￥875.00
    700.00
    - +
  • 1mg
    ￥1575.00
    1260.00
    - +
  • 5mg
    ￥3037.00
    2430.00
    - +
  • 10mg
    ￥5162.00
    4130.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci74422
  • CAS: 78-41-1
  • 别名: 曲帕拉醇,MER-29
  • 分子式: C27H32ClNO2
  • 分子量: 438
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.125 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol. It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model. It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.

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