Viridicatol

A fungal metabolite

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库存: 现货

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数量
1mg

￥2062.00

1650.00

- +
5mg

￥5175.00

4140.00

- +
10mg

￥8312.00

6650.00

- +
25mg

￥16562.00

13250.00

- +

已选 0 种 0 瓶

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货号: ajci74536
CAS: 14484-44-7
别名: 纯绿青霉醇
分子式: C15H11NO3
分子量: 253.3
纯度: >98%
溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay. It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM).