(-)-(α)-Kainic Acid (hydrate)

An L-glutamate analog with neuroexcitatory activities

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5mg

￥1150.00

920.00

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10mg

￥2162.00

1730.00

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25mg

￥4800.00

3840.00

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50mg

￥8475.00

6780.00

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Background

Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice.[1] Kainic acid is neuroexcitotoxic and epileptogenic, acting through specific kainate receptors.[2] 芥酸是一种最初从红海藻D. Simplex中分离出的天然海洋产物。它是一种强效的中枢神经系统兴奋剂，已被开发为诱导实验动物癫痫发作的原型神经兴奋性氨基酸，对小鼠的典型剂量为10-30 mg/kg。[1] 芥酸是一种神经兴奋毒性和癫痫毒性物质，通过特异性的芥子酸受体发挥作用。[2]

Reference:
[1]. Marsicano, G., Goodenough, S., Monory, K., et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302(5642), 84-88 (2003).
[2]. Ferkany, J.W., Zaczek, R., and Coyle, J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298(19), 757-759 (1982).