20-Deoxyingenol

A diterpenoid with antioxidant and osteoprotective activities

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5mg

￥1087.00

870.00

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10mg

￥1937.00

1550.00

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货号: ajce44264
CAS: 54706-99-9
别名: 20-去氧巨大戟醇；20-去氧巨大戟萜醇
分子式: C20H28O4
分子量: 332.43
纯度: >98%
溶解度: DMSO : 50 mg/mL (150.41 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

20-Deoxyingenol is a diterpenoid that has been found in E. kansui and has antioxidant and osteoprotective activities.^1,2 It inhibits oxidative stress-induced decreases in autophagic flux and apoptosis in isolated mouse chondrocytes when used at a concentration of 10 mM.² 20-Deoxyingenol (20 mg/kg per day, i.p.) reduces bone erosion and cartilage calcification in joints in a mouse model of injury-induced osteoarthritis.

1.Zhang, J.-S., Weng, H.-Z., Huang, J.-L., et al.Anti-inflammatory ingenane diterpenoids from the roots of Euphorbia kansuiPlanta Med.84(18)1334-1339(2018) 2.Gu, M., Jin, J., Ren, C., et al.20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytesPharmacol. Res.165105361(2021)