GLP-1(7-37)

An incretin hormone

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥2262.00

1810.00

- +
5mg

￥3850.00

3080.00

- +
10mg

￥5875.00

4700.00

- +
25mg

￥9625.00

7700.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

Glucagon-like peptide 1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.¹ It binds to βTC-1 and RIN 1027-B2 cells (K_ds = 3.3 and 3.5 nM, respectively) and enhances insulin secretion in βTC-1 cells in a concentration- and glucose-dependent manner.² Ex vivo, GLP-1 (7-37) stimulates insulin release from perfused rat pancreas.¹ GLP-1 (7-37) increases plasma insulin concentrations by greater than 50% as compared to vehicle control in response to hyperglycemia in rats when administered at a dose of 15 pmol/min/kg for five days.³

1.Mojsov, S., Weir, G.C., and Habener, J.F.Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreasJ. Clin. Invest.79(2)616-619(1987) 2.Fehmann, H.C., and Habener, J.F.Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell lineFEBS Lett.279(2)335-340(1991) 3.Hargrove, D.M., Nardone, N.A., Persson, L.M., et al.Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administrationMetabolism44(9)1231-1237(1995)