E3 ligase Ligand 4

A precursor in the synthesis of PROTACs

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100mg

￥1412.00

1130.00

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500mg

￥2937.00

2350.00

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1g

￥0.00

0.00

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2g

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货号: ajce44570
CAS: 835616-60-9
别名: 2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮,Cereblon ligand 4; E3 ligase Ligand 4
分子式: C13H9FN2O4
分子量: 276.22
纯度: >98%
溶解度: DMSO : 200 mg/mL (724.06 mM)
储存: Store at -20°C
库存: 现货

Background

TC-E3 5032 is a precursor in the synthesis of homodimeric proteolysis-targeting chimera technologies (PROTACs).¹ It has been used to attach various linkers at position 4 to produce alkylated pomalidomide derivatives as intermediates in the synthesis of homodimeric PROTACs. It has also been used as an intermediate in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders.^2,3

1.Steinebach, C., Lindner, S., Udeshi, N.D., et al.Homo-PROTACs for the chemical knockdown of cereblonACS Chem. Biol.13(9)2771-2782(2018) 2.Yang, K., Song, Y., Xie, H., et al.Development of the first small molecule histone deacetylase 6 (HDAC6) degradersBioorg. Med. Chem. Lett.28(14)2493-2497(2018) 3.Powell, C.E., Gao, Y., Tan, L., et al.Chemically induced degradation of anaplastic lymphoma kinase (ALK)J. Med. Chem.61(9)4249-4255(2018)