L-SelenoMethionine

A naturally occurring amino acid with antioxidant properties

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100mg

￥600.00

480.00

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500mg

￥1612.00

1290.00

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Background

L-Selenomethionine (SeMet), a naturally occurring amino acid, is the predominant form of selenium found in Brazil nuts, grains, soy beans, and legumes.¹ It promotes cell cycle progression and is known to elevate the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase, and glutathione peroxidase.^2,3,4 At 5 ?M, SeMet has been shown to selectively induce apoptosis in LNCaP prostate cancer cells without affecting non-cancerous cells.⁵

1.Schrauzer, G.N.Selenomethionine: A review of its nutritional significance, metabolism and toxicityJ. Nutr.130(7)1653-1656(2000) 2.Zeng, H.Selenite and selenomethionine promote HL-60 cell cycle progressionJ. Nutr.132(4)674-679(2002) 3.El-Sayed, W.M., Aboul-Fadl, T., Roberts, J.C., et al.Murine hepatoma (Hepa1c1c7) cells: A responsive in vitro system for chemoprotective enzyme induction by organoselenium compoundsToxicol. In Vitro21(1)157-164(2007) 4.Jornot, L., and Junod, A.F.Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cellsBiochem. J.306(Pt 2)581-587(1995) 5.Stewart, J., Ware, J., Boysen, C., et al.Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progressionNutr. Cancer60(6)826-836(2008)