Mirogabalin (DS5565)

A calcium channel blocker

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库存: 现货

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1mg

￥562.00

450.00

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5mg

￥1300.00

1040.00

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10mg

￥2062.00

1650.00

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25mg

￥3262.00

2610.00

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50mg

￥5287.00

4230.00

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100mg

￥8100.00

6480.00

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货号: ajce45988
CAS: 1138245-13-2
别名: 米洛巴林,DS5565
分子式: C12H19NO2
分子量: 209.28
纯度: >98%
溶解度: Methanol : 16 mg/mL (76.45 mM);Water : 7.71 mg/mL (36.84 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

Mirogabalin is a calcium channel blocker with analgesic effects.¹ It binds to the α₂δ-1 and α₂δ-2 subunits of voltage-dependent Ca²⁺ channels. Mirogabalin has potent and sustained analgesic effects (ED₅₀ = 2.5 mg/kg) in rats with diabetes induced by streptozotocin . Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID₅₀ = 9.4 mg/kg) or locomotor activity (ID₅₀ = 43.9 mg/kg), at its effective dose.

1.Brown, K., Ohwada, S., Warren, V., et al.(405) A single ascending-dose study of mirogabalin in healthy subjects: Safety, tolerability, pharmacokinetic, and pharmacodynamic results.J. Pain17(4S)S76(2016)