DLK-IN-1

DLK-IN-1是双亮氨酸拉链激酶(DLK,MAP3K12)的选择性抑制剂，其Ki值为3nM。DLK-IN-1保持着良好的中枢神经系统穿透能力，并且在脑内剂量过量后依旧耐受性良好，在阿尔兹海默症动物模型中有良好的活性。

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库存: 现货

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促销价

数量
5mg

￥5875.00

4700.00

- +
10mg

￥9087.00

7270.00

- +
25mg

￥18525.00

14820.00

- +
50mg

￥29137.00

23310.00

- +
100mg

￥41850.00

33480.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer's Disease.

[1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.