Leuprorelin (Leuprolide)

Leuprolide是一种垂体GnRH受体激动剂。

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库存: 现货

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1mg

￥775.00

620.00

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5mg

￥2325.00

1860.00

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10mg

￥3625.00

2900.00

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货号: ajce46242
CAS: 53714-56-0
别名: 亮丙瑞林
分子式: C59H84N16O12
分子量: 1209.4
纯度: >98%
溶解度: >20.6 mg/mL in H2O; >22 mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

Leuprolide is an agonist at pituitary GnRH receptors. Target: GnRH receptorLeuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones. [1] By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. [2]

[1]. Plosker GL, Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders. Drugs.1994 Dec;48(6):930-967. [2]. Leuprorelin