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NMI 8739的可视化放大

NMI 8739

A conjugate of DHA and dopamine

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NMI 8739的二维码
  • 库存: 现货
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  • 包装
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    促销价
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  • 1mg
    ¥750.00
    600.00
    - +
  • 5mg
    ¥2037.00
    1630.00
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  • 10mg
    ¥3125.00
    2500.00
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  • 25mg
    ¥6300.00
    5040.00
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  • 货号: ajce46464
  • CAS: 129024-87-9
  • 别名: DHA-DA, NMI 8739
  • 分子式: C30H41NO3
  • 分子量: 463.65
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 100 mg/mL (215.68 mM); Ethanol: 100 mg/mL (215.68 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

N-Docosahexaenoyl dopamine (DHA-DA) is an amine conjugate of the neurotransmitter dopamine and the polyunsaturated fatty acid docosahexaenoic acid . DHA-DA is actively transported into the brain following intraperitoneal injections in mice, resulting in reduced general locomotor activity of 35-40% at a dose of 5 mg/kg.1 It is theorized that the DHA portion of the molecule serves as a carrier for DA through the blood-brain barrier via a DHA-mediated transport system.1 DHA-DA exhibits immune-modulating, anti-inflammatory activity in the range of 0.1-2.5 ?M, suppressing the production of nitric oxide, IL-6, CCL20, MCP-1, and PGE2 in LPS-stimulated macrophages and microglial cells without affecting NF-κB activity.2


1.Shashoua, V.E., and Hesse, G.W.N-Docosahexaenoyl, 3-hydroxytyramine: A dopaminergic compound that penetrates the blood-brain barrier and suppresses appetiteLife Sci.58(16)1347-1357(1996) 2.Wang, Y., Plastina, P., Vincken, J.-P., et al.N-docosahexaenoyl dopamine, an endocannabinoid-like conjugate of dopamine and the n-3 fatty acid docosahexaenoic acid, attenuates lipopolysaccharide-induced activation of microglia and macrophages via COX-2ACS Chem. Neurosci.Epub ahead of print(2016)

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