β-Amyloid 29-40 (Amyloid beta-protein(29-40))

β-Amyloid 29-40 (Amyloid beta-protein(29-40)) 是 Amyloid-&#946 的一个片段；肽。

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库存: 现货

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1mg

￥862.00

690.00

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5mg

￥2587.00

2070.00

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10mg

￥4175.00

3340.00

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Background

β-Amyloid (29-40) is a fragment of Amyloid-β peptide.

β-Amyloid (29-40) is a fragment of Amyloid-β peptide, unsoluble in water, acetonitrile or in a mixture of both in different ratios. Cationic arginine residues is introduced at β-Amyloid (29-40) C-terminus to solubilize β-Amyloid (29-40) and introduce cationicity in this Aβ stretch to enable it to interact with the negatively charged membrane of bacteria. β-Amyloid (29-40) variants shows antimicrobial effect[1]. Single chain variable fragments (scFv's) binds the 17-28 region of Abeta and effectively inhibits in vitro aggregation of Abeta, but binding the carboxyl-terminal region of β-Amyloid (29-40) does not inhibit aggregation[2].

[1]. Harioudh MK, et al. A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity. Chem Commun (Camb). 2017 Dec 5;53(97):13079-13082. [2]. Liu R, et al. Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry. 2004 Jun 8;43(22):6959-67.