Physalaemin

Physalaemin是一种非哺乳动物类的速激肽，选择性地高亲和力结合到神经激肽-1(NK1)受体。

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库存: 现货

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促销价

数量
1mg

￥812.00

650.00

- +
5mg

￥1612.00

1290.00

- +
10mg

￥2262.00

1810.00

- +
25mg

￥4700.00

3760.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized[1]. Physalaemin is a bradykinin potentiating peptide (BPP-5a)[2].

[1]. Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. [2]. Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31.