β-Amyloid 1-28 (Amyloid β-Protein (1-28))

β-Amyloid 1-28 (Amyloid β-Protein (1-28)) 是 β-Amyloid 蛋白片段，参与金属结合。

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1mg

￥1712.00

1370.00

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5mg

￥6850.00

5480.00

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Background

β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab-Cu2+ interaction[1]. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of Ka10 7 M-1[2].

[1]. Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95(4):270-82. [2]. Syme CD, et al. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques. J Biol Chem. 2004 Apr 30;279(18):18169-77.