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Aldose reductase-IN-1

An aldose reductase inhibitor

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Aldose reductase-IN-1的二维码
  • 库存: 现货
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  • 5mg
    ¥1512.00
    1210.00
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  • 10mg
    ¥2150.00
    1720.00
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  • 50mg
    ¥8562.00
    6850.00
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  • 100mg
    ¥13775.00
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  • 货号: ajce46994
  • CAS: 1355612-71-3
  • 别名: Aldose reductase-IN-1; AT-001
  • 分子式: C17H10F3N5O3S
  • 分子量: 421.35
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 28 mg/mL (66.45 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

AT-001 is an inhibitor of aldose reductase (IC50 = 28.9 pM).1 It reduces infarct area in streptozotocin-induced diabetic mice expressing human aldose reductase in a model of cardiomyopathy induced by ischemia-reperfusion injury when administered at a dose of 40 mg/kg.2


1.Wasmuth, A., Landry, D., Deng, S.X., et al.Aldose reductase inhibitors and uses thereof(2014) 2.Perfetti, R., Rowell, P., Shendelman, S., et al.Preclinical and clinical proof of concept for metabolic intervention in diabetic cardiomyopathyJ. Card. Fail.25(8)S77(2019)

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