EX229

An AMPK activator

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5mg

￥1212.00

970.00

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10mg

￥1737.00

1390.00

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25mg

￥3487.00

2790.00

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50mg

￥6037.00

4830.00

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Background

EX-229 is an activator of AMP-activated protein kinase (AMPK).¹ It activates AMPK and increases glucose uptake in isolated rat epitrochlearis muscle when used at a concentration of 100 ?M. EX-229 also increases AMPK activation and glucose uptake in primary skeletal muscle cultures isolated from patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).²

1.Lai, Y.-C., Kviklyte, S., Vertommen, D., et al.A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: Comparison with effects of contraction and other AMPK activatorsBiochem. J.460(3)363-375(2014) 2.Brown, A.E., Dibnah, B., Fisher, E., et al.Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFSBiosci. Rep.38(3)BSR20180242(2018)