Tiaprost (Iliren)

A synthetic analog of PGF2α

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库存: 现货

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数量
1mg

￥2375.00

1900.00

- +

已选 0 种 0 瓶

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货号: ajce47132
CAS: 71116-82-0
别名: 噻前列素,Iliren
分子式: C20H28O6S
分子量: 396.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin F_2α plays a central role in luteolysis. Tiaprost is a synthetic analog of PGF_2α that is used in veterinary medicine as an estrus-synchronizing agent.¹ It has also been used to treat endometritis and to induce parturition.^2,3

1.Yadav, V.K., Sudhagar, R.R., and Medhamurthy, R.Apoptosis during spontaneous and prostaglandin F2α-induced luteal regression in the buffalo cow (Bubalus bubalis): Involvement of mitogen-activated protein kinasesBiol. Reprod.67752-759(2002) 2.Sheldon, I.M., Lewis, G.S., LeBlanc, S., et al.Defining postpartum uterine disease in cattleTheriogenology651516-1530(2006) 3.Holtz, W., Schmidt-Baulain, R., Meyer, H., et al.Control of prostaglandin-induced parturition in sows by injection of theβadrenergic blocking agent carazolol or carazolol and oxytocinJ. Anim. Sci.683967-3971(1990)

Protocol

Animal experiment:

Cows[1]Six healthy dairy cows of the German Black Pied breed, pregnant for 190 to 266 days, are treated initially with 0.75 mg of the PGF2α analog Tiaprost SC (treatment day=day 0). All animals are moved to the department’s large animal hospital 5 to 20 days before treatment commenced; they are kept in stanchions and fed. All animals are examined clinically daily and rectally as well as vaginally at two- to six-day intervals[1].

参考文献:

[1]. Grunert E, et al. Delayed termination of third-trimester gestations in dairy cows after treatment with the PGF(2alpha)analog Tiaprost. Theriogenology. 1984 May;21(5):823-34.