H-Val-Pro-Pro-OH

A peptide ACE inhibitor

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库存: 现货

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数量
5mg

￥700.00

560.00

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10mg

￥1075.00

860.00

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25mg

￥2262.00

1810.00

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货号: ajce47300
CAS: 58872-39-2
别名:
分子式: C15H25N3O4
分子量: 311.38
纯度: >98%
溶解度: 125 mg/mL in Water(Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

H-Val-Pro-Pro-OH (VPP) is a peptide inhibitor of angiotensin-converting enzyme (ACE; IC₅₀ = 9 ?M).¹ It inhibits acetylcholine-induced nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 ?M and induces vasorelaxation in precontracted isolated rat aortic rings.² VPP (0.3 mg/kg) decreases systolic blood pressure in spontaneously hypertensive, but not normotensive, rats.³ Dietary administration of VPP reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, expression of Il6 and Il1b, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE^-/- mice.⁴

1.Nakamura, Y., Yamamoto, N., Sakai, K., et al.Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milkJ. Dairy Sci.78(4)777-783(1995) 2.Hirota, T., Nonaka, A., Matsushita, A., et al.Milk casein-derived tripeptides, VPP and IPP induced NO production in cultured endothelial cells and endothelium-dependent relaxation of isolated aortic ringsHeart Vessels26(5)549-556(2011) 3.Nakamura, Y., Yamamoto, N., Sakai, K., et al.Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzymeJ. Dairy Sci.78(6)1253-1257(1995) 4.Nakamura, T., Hirota, T., Mizushima, K., et al.Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: A preliminary studyJ. Med. Food16(5)396-403(2013)