3-Methyl-L-histidine

An amino acid

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100mg

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Background

3-Methyl-L-histidine is an endogenous amino acid and a component of the skeletal muscle proteins actin and myosin.^1,2,3 It is released during the catabolism of muscle fibrillar protein and excreted in urine.³ Urinary levels of 3-methyl-L-histidine are decreased in children with protein-energy malnutrition compared with well-nourished control subjects. 3-Methyl-L-histidine has been used as a biomarker of skeletal muscle catabolism.^1,2,3

1.Lukaski, H.C., Mendez, J., Buskirk, E.R., et al.Relationship between endogenous 3-methylhistidine excretion and body compositionAm. J. Physiol.240(3)E302-E307(1981) 2.Lowry, S.F., Horowitz, G.D., Jeevanandam, M., et al.Whole-body protein breakdown and 3-methylhistidine excretion during brief fasting, starvation, and intravenous repletion in manAnn. Surg.202(1)21-27(1985) 3.Nagabhushan, V.S., and Narasinga Rao, B.S.Studies on 3-methylhistidine metabolism in children with protein-energy malnutritionAm. J. Clin. Nutr.31(8)1322-1327(1978)