CCK-Areceptorinhibitor1是一种缩胆囊素A(cholecystokininA,CCK-A)受体抑制剂,IC50为340nM。
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CCK-A receptor inhibitor 1 is a cholecystokinin A (CCK-A) receptor inhibitor with a binging IC50 of 340 nM.
CCK-A receptor inhibitor 1 (Compound 7c) is a naphthyl sulfone derivative, which is synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities are found in CCK-A receptor inhibitor 1 having very hydrophobic sidechains[1].
[1]. Ajisawa Y, et al. [Studies on the synthesis of cholecystokinin A receptor antagonists. III. Synthesis and cholecystokinin A receptor inhibitory activities of naphthyl sulfone derivatives]. Yakugaku Zasshi. 1996 Aug;116(8):647-56.
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