NNC45-0781

NNC45-0781是一种组织选择性的雌激素(estrogen)部分激动剂。

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库存: 现货

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数量
1mg

￥8350.00

6680.00

- +
5mg

￥16525.00

13220.00

- +
10mg

￥28075.00

22460.00

- +
20mg

￥49587.00

39670.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

NNC45-0781 is a tissue-selective estrogen partial-agonist.

NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group[1].

[1]. Bury PS, et al. Synthesis and pharmacological evaluation of novel cis-3,4-diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor. Bioorg Med Chem. 2002 Jan;10(1):125-45.

Protocol

Animal experiment:

Rats[1]Female Sprague-Dawley rats, 12 weeks of age, weighing approximately 250 g are used in these studies.The pharmacological properties of NNC45-0781 (NNC 45-0781) are studied through a series of in vivo experiments. Activity of orally administered NNC45-0781 (1,10, 50 and 100 nmol/g) on total serum cholesterol in the ovariectomized rat.

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