AZD2098

A CCR4 receptor antagonist

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库存: 现货

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数量
1mg

￥812.00

650.00

- +
5mg

￥1100.00

880.00

- +
10mg

￥1900.00

1520.00

- +
20mg

￥4825.00

3860.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce47566
CAS: 566203-88-1
别名:
分子式: C11H9Cl2N3O3S
分子量: 334.18
纯度: >98%
溶解度: DMSO : 100 mg/mL (299.24 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

AZD 2098 is a CC chemokine receptor 4 (CCR4) antagonist.¹ AZD 2098 inhibits CCL22-induced calcium flux in CHO cells expressing human recombinant CCR4 (IC₅₀ = 31.6 nM) and CCL22- and CCL17-mediated Th2 cell chemotaxis (IC₅₀ = 501.2 nM for both). AZD 2098 is selective for CCR4 over CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 up to 10 ?M in vitro. Administration of AZD 2098 (0.07-2.5 mg/kg, p.o.) to ovalbumin-sensitized, antigen-challenged rats reduces alveolitis and leukocyte infiltration in the lung in a dose-dependent manner.

1.Kindon, N.D., Andrews, G., Baxter, A., et al.Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonistsMed. Chem.8(9)981-986(2017)